Abstract: As a widely used brominated flame retardant，hexabromocyclododecane ( HBCD) has been used in various industries for a long period of time. The environmental pollution and human health problems caused by HBCD have significantly attracted international communities，attention. Monitoring and exposure risk assessment of HBCD in aquatic products has become a national and international research hotspot. This paper reviewed the determination methodologies，and pollution levels of HBCD in aquatic products. The pros and cons of each method were compared to provide accurate determination of HBCD in aquatic products. Further investigations on the sources，biomagnification and potential hazard to human health of HBCD in aquatic prod-ucts are necessary.